Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging.Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation.TRIB2 deficiency increases AKT activity

Pressure garment therapy is often prescribed to improve scar properties following full-thickness burn injuries.Pressure garment therapy is generally recommended for long periods of time following injury (1-2 years), though it is plagued by extremely low patient compliance.The goal of this study was to examine the effects of Body early cessation of

Fibroblast growth factor 2 (FGF2 or basic FGF) regulates a wide range of cell biological functions including proliferation, angiogenesis, migration, differentiation, and injury repair.However, the roles of FGF2 and the underlying mechanisms of action in influenza A virus (IAV)-induced lung injury remain largely unexplored.In this study, we report t

Introduction: Social and familial stigma and prejudices make treatment-seeking difficult in women substance abusers.An analysis of various social, familial, personal, and other correlates of the treatment seekers can help in an appropriate understanding of the problem and can help in a better assessment, management and prevention of this problem.Ai