TRIB2 safeguards naive T cell homeostasis during aging

Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging.Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation.TRIB2 deficiency increases AKT activity

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Factors related to female substance abuse: A hospital based study from a tertiary care de-addiction center in India

Introduction: Social and familial stigma and prejudices make treatment-seeking difficult in women substance abusers.An analysis of various social, familial, personal, and other correlates of the treatment seekers can help in an appropriate understanding of the problem and can help in a better assessment, management and prevention of this problem.Ai

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